The first generation of Laboratory Information Management Systems came about in 1982 with the first automated reporting tools. Since then, the concept has developed into a modern-day software-as-a-service for laboratories, big and small. These digital services allow the operation of a laboratory by providing various management, instrument, application, and financial services. As LIMS companies continue to redefine what a LIMS is, the future of this sector has evolved with the occurrence of a global pandemic crisis. As e-commerce becomes the norm, institutions begin to opt for web-based technological solutions. Opting for thin-client LIMS allows the user to process data using Cloud-based LIMS, with all data being uploaded to the cloud, where information is processed. By providing, improving, and optimizing biobanking capabilities, LIMS has helped the reopening of research laboratories during COVID-19 times, by providing an effective workflow and allowing laboratories to meet safety requirements before and after they begin to operate. LIMS systems are helping researchers develop, standardize, and test out methods of testing COVID-19. With LIMS, laboratories can automate and streamline data entry and integrate special COVID analytic instruments for carrying out testing. Some LIMS companies have released mobile compatible applications for portability. Registering patient demographics speeds up testing, reduces errors, and optimizes research, which makes up important aspects of public healthcare. With science and technology becoming an important discipline of humanity, the LIMS companies are indeed creating magic in the digitization of the health sector by acting as the tech-skeletons of these laboratory operations.